Reprofiling Hydrogen Peroxide from Antiseptics to Pyolytics: A Narrative Overview of the History of Inventions in Russia

Pyolytics are drugs that dissolve thick pus when applied topically. This group of was discovered in early 21st century Russia as a result successful repurposing antiseptics hydrogen peroxide, sodium bicarbonate and chloride from to pyolytics. Prior this watershed event pharmacy, the problem effective treatment purulent diseases had not been solved. The fact is before various mainly disinfectants solutions were used, which hypertonic solution 3 - 6% peroxide took leading role "antipurulent" drugs. However, use known provided disinfection treated surface, but dissolution masses, no pyolytic action. Pyolytic activity, i.e. activity fantastically increased only after possibility transformation "old" into "new" by means artificial changes physical chemical properties their dosage forms discovered. greatest (explosive) effect achieved developing warm alkaline enriched with oxygen gas under pressure. In chronological order, an overview given Russian inventions, formed basis for physicochemical pyolytics well temperature pharmacology pharmaceutics.